The US-born giant panda Bei Bei has left his home at Washington's National Zoo for China.
Bei Bei will travel on a specially equipped flight from Washington to Chengdu, accompanied by his keeper and a veterinarian.
The giant panda turned four years - the age when all pandas born outside return to China under their breeding agreements.
"Today is bittersweet. We've cared for Bei Bei, and along with millions, watched him grow into a true ambassador for his species," said zoo director Steve Monfort.
"We look forward to continuing our 47-year giant panda conservation program and collaboration with Chinese colleagues to study, care for and help save the giant panda and its native habitat."
Zoo officials said they had prepared a special stash of treats for him: 30 kilos of bamboo, two pounds of apples and pears, two pounds of cooked sweet potatoes, two bags of biscuits and water.
President Donald Trump has reimposed a naval blockade of all Iranian ports on Tuesday and threatened to hit power plants and bridges next week unless Tehran resumes negotiations as the US military completed another round of strikes on Iran.
Kuwait's Ministry of Defence has reported the injury of four service members after Iranian attacks targeted the country's Navy vessel on Tuesday evening as its air defence forces intercepted six missiles and 33 drones.
The number of confirmed Ebola cases in the Democratic Republic of Congo has increased to 2,011, including 754 deaths, government data showed on Tuesday.
One person has died, and two others were missing on Tuesday after a triple-deck pontoon boat with 19 people aboard capsized near Alcatraz Island in San Francisco Bay, officials said.
Britain will introduce a default overnight curfew on social media apps for 16- and 17-year-olds, the government said, adding new restrictions for older teenagers to its plan to introduce a sweeping ban on social media for under-16s.